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Glutathione for Radiant Skin: A Scientific Exploration

In the realm of dermatology, the pursuit of effective and safe skincare interventions is ceaseless. A noteworthy addition to this quest is the study titled "Glutathione and its Antiaging and Antimelanogenic Effects," published in Clinical, Cosmetic, and Investigational Dermatology.

Understanding Glutathione: A Skin-Enriching Molecule

Glutathione, a pivotal antioxidant in the body, has intrigued researchers for its potential skin benefits. Authored by Sinee Weschawalit et al., this study delves into the antiaging and antimelanogenic effects of both reduced (GSH) and oxidized (GSSG) forms of glutathione.

Study Design: Unraveling the Impact

The researchers conducted a randomized, double-blind, placebo-controlled study involving healthy female subjects. Divided into three groups, participants received oral supplementation of GSH (250 mg/d), GSSG (250 mg/d), or a placebo for 12 weeks. Skin parameters, including melanin index, wrinkles, and various biophysical properties, were meticulously assessed.

Key Findings: Illuminating Skin Improvement

The results painted a promising picture. Both GSH and GSSG, even at a modest daily dose of 250 mg, exhibited a tendency to reduce melanin index and UV spots across multiple skin sites, including the face and arms. Notably, GSH demonstrated a significant reduction in wrinkles at specific sites compared to the placebo group. There was also a positive trend toward increased skin elasticity in both GSH and GSSG groups.

Safety First: A Well-Tolerated Intervention

Crucially, the study emphasized the safety profile of glutathione supplementation. Subjects experienced no serious adverse effects throughout the 12-week period, affirming the tolerability of oral glutathione, both in its reduced and oxidized forms.

Conclusion: A Radiant Future for Skincare

In conclusion, this study illuminates the positive impact of oral glutathione, even at lower doses, on various skin parameters. The findings invite further exploration of glutathione as a valuable asset in the pursuit of radiant and healthy skin.


Weschawalit S, Thongthip S, Phutrakool P, Asawanonda P. Glutathione and its antiaging and antimelanogenic effects. Clin Cosmet Investig Dermatol. 2017;10:147-153. doi: 10.2147/CCID.S128339. PMID: 28490897; PMCID: PMC5413479.

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